Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes

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Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes.

BACKGROUND Combinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania. AIMS To assess the efficacy and safety of olanzapine plus carbamazepine in mixed and manic bipolar episodes. METHOD Randomised, double-blind, 6-week trial of olanzapine (10-30 mg/day) plus carbamazepine (400-1200 mg/day; n=58) v. placebo plus carbamazepine (n=60) followed ...

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The Use of Carbamazepine in Patients with Manic Depressive Illness

16 cases of affective disorder were studied. 8 patients received carbamazepine and 8 received either chlorpromazine or imipramine. Ratings were carried out on the Hamilton Rating Scale for Depression, Bech Rafaelsen Mania Rating scale and a side-effects symptom check list. Garbamazepine was found to be an effective treatment for affective disorders, possessing both anti-manic as well as anti-de...

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Summary of the Recent Literature on Bipolar Disorder

Acute Mania Quetiapine XR (FDA approved for the treatment of acute mania) monotherapy has been shown to be more effective than placebo in treating acute mania with improvement starting at day 4. Aripiprazole adjunctive therapy was more effective than placebo adjunctive therapy in treating manic symptoms in BD manic patients with inadequate response to lithium or divalproex in a 6 week trial. Ol...

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Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion

Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxid...

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Carbamazepine oral suspension (100mg/5ml), 100mg and 200mg chewable tablets are proposed for addition to the Model List of Essential Medicines, for use in the management of epilepsy in children. It is at least as effective as phenobarbitone, phenytoin and sodium valproate in the management of partial and tonic-clonic seizures in children. Carbamazepine is available in the UK as a sugar free ora...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 2008

ISSN: 0007-1250,1472-1465

DOI: 10.1192/bjp.bp.107.041301